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CAS Number: 622864-54-4
Neratinib weakly inhibits tyrosine kinases KDR and Src with IC50 of 0
phenserine
21)22/h5-8H
S2157 rrin CAS Number: 622864-54-4S2157, a N alkylated tranylcypromine (TCP) derivative, is a potent lysine specific demethylase 1 (LSD1) inhibitor. S2157 increases H3K9 methylation and reciprocal H3K27 deacetylation at super enhancer regions. S2157 induces apoptosis in TCP resistant T cell acute lymphoblastic leukemia (T ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2157 efficiently pass through the blood brain barrier and can almost completely eradicate CNS
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